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张 济

研究员,博士生导师

肿瘤遗传学及表观遗传学研究课题组组长
Email: jizhang@sibs.ac.cn

> 研究方向

目前研究重点为:(1)白血病染色质动态信息与维甲酸诱导分化的关联;(2) 实体瘤转移的调控网络;(3)相关生物标志物的识别。

> 学习经历

1978.2-1982.1:新疆大学生物系,生物学士
1986.9 -1991.7:比利时鲁汶大学医学院人类遗传中心,医学科学博士

> 工作简历

1991-1993:美国密西根大学,放射肿瘤学,博士后
1993-1999:美国NIH人类基因组学研究,Senior Staff Fellow
1999..-2003: 美国内布拉斯加州大学医学院,助理教授

> 荣誊

中科院“百人计划”(04年):自然基金“杰青”(03年,海外合作基金):上海交通大学“特聘教授”(15年):上海科技进步一等奖,教育部科技进步一等奖等。

> 近期主要论文

1.Fang H, Yang, Y, Li CL, … Zhang J. & Jin Y. Transcriptome Analysis of Early Organogenesis in Human Embryos. Developmental Cell, 19(1), pp 174-184, 2010

2.Wang KK, Wang P, Shi JT,…Zhang J. PML/RARa Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia. Cancer Cell 2010, 17, 186–197

3.Zhang YX, Du YZ, Le WD, … Zhang J. Redox Control of the Survival of Healthy and Diseased cells. Antioxid Redox Signal, 15(11), pp 2867-2908, 2011/11/11

4.Zhang YX, Wang C, Wang HW, … Zhang J. Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo. Cancer Letters, 304(1), pp 21-32, 2011/1/24

5.Jiang L, Pan X, Chen Y, … Zhang J. Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells. Biochemical and Biophysical Research Communications, 405 (Jaunery2011), pp 314-318,

6.Wu K, Dong D, Fang H,… Neyrolles O. & Zhang J. An interferon-related signature in the transcriptional core response of human macrophages to mycobacterium tuberculosis infection. Plos One, 7(6), 2012

7.Du YZ, Xia, Y, Pan, XL, … Zhang J. Fenretinide Targets Chronic Myeloid Leukemia Stem/Progenitor Cells by Regulation of Redox Signaling. Antioxid Redox Signal, Issue 10.1089 493, 2013

8.Qian MX, Jin W, Zhu XH, … Zhang J. Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. Journal of Hematology and Oncology, Vol 6, p 25, 2013