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诸 江

研究员,博士生导师

造血细胞信号转导和白血病干细胞研究课题组组长
Email: zhujiang@shsmu.edu.cn

> 研究方向

目前研究重点为:(1) 白血病干性的异质性和诱导分化疗法;(2) Rig-I相关分子生物学;(3) 造血微环境。

> 学习经历

1988-1991:苏州医学院,免疫学硕士
1993-1996:上海第二医科大学,内科血液学博士

> 工作简历

1990-2005:美国University of Pennsylvania博士后 (Postdoctoral Research Associate)
2005-至今:上海交通大学附属瑞金医院上海血液学研究所课题组长

> 荣誊

2009:上海优秀学科带头人

> 近期主要论文

1. Jiang, L.J., Zhang, N.N., Ding, F., Li, X.Y., Chen, L., Zhang, H.X., Zhang, W., Chen, S.J., Wang, Z.G., Li, J.M., et al. (2011). RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 108, 1897-1902.

2. Li, X.Y., Jiang, L.J., Chen, L., Ding, M.L., Guo, H.Z., Zhang, W., Zhang, H.X., Ma, X.D., Liu, X.Z., Xi, X.D., et al. (2014). RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Molecular cell 53, 407-419.

3. Zhang, H.X., Liu, Z.X., Sun, Y.P., Zhu, J., Lu, S.Y., Liu, X.S., Huang, Q.H., Xie, Y.Y., Zhu, H.B., Dang, S.Y., et al. (2013). Rig-I regulates NF-kappaB activity through binding to Nf-kappab1 3'-UTR mRNA. Proceedings of the National Academy of Sciences of the United States of America 110, 6459-6464.

4. Zhang, W., Ding, M.L., Zhang, J.N., Qiu, J.R., Shen, Y.H., Ding, X.Y., Deng, L.F., Zhang, W.B., and Zhu, J. (2015). mTORC1 maintains the tumorigenicity of SSEA-4(+) high-grade osteosarcoma. Scientific reports 5, 9604.