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童建华

研究员,博士生导师

肿瘤细胞分化和凋亡途径研究共同课题组长
Email: jh_tong@126.com

> 研究方向

目前研究重点:(1)肿瘤(白血病)细胞分化、增殖、凋亡等相关信号转导途径;(2)人类疾病(特别是肿瘤)靶标或生物标志物的研究;(3)新的分化(或凋亡)诱导剂的筛选与作用机制研究。

> 学习经历

1984-1988:上海复旦大学生物工程系遗传与遗传工程专业,学士
1993-1994:法国巴黎第七大学肿瘤分子生物学专业,DRUS
1994-1997:法国巴黎第七大学人类遗传学,博士

> 工作简历

1988-1990:上海第二医科大学检验系生化教研室
1990-2013:上海交通大学医学院附属瑞金医院上海血液学研究所
1993-1997:法国巴黎圣路易医院血液研究所
2013-至今:上海交通大学医学院附属瑞金医院检验系主任

> 国家级与省部级科研项目

国家“863”计划(2001AA227071)
国家973基础研究发展规划项目(2002CB512805)
国家863计划(2006AA02Z19A)
国家自然基金面上项目(30070416)
国家自然基金面上项目(30271466)
国家自然基金面上项目(30570778)
国家自然基金面上项目(30971275)
国家自然科学基金面上项目(81170508)
国家自然科学基金面上项目(81470317)

> 荣誊

2013年获国务院政府特殊津贴
2010中华医学科技奖,一等奖
2009上海市自然科学奖,一等奖
2009年入选新世纪百千万人才工程国家级人选
2008上海医学科技奖,一等奖
2008教育部高校自然科学奖,一等奖

> 近期主要论文

1. Lou Y-J, Pan X-R, Jia P-M, Jin J, Tong J-H. RIG-G inhibits the proliferation of NB4 cells and propels ATRA-induced differentiation of APL cells. Leukemia Research, 2016, 40, 83-89
2. Zhuang L-K, Xu G-P, Pan X-R, Lou Y-J, Zou Q-P, Xia D, Yan W-W, Zhang Y-T, Jia P-M, Tong J-H. MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation. Cell Death & Disease, 2014, 5, e1161.
3. Xu G-P, Zhang Z-L, Xiao S, Zhuang L-K, Xia D, Zou Q-P, Jia P-M, Tong J-H. Rig-G negatively regulates SCF-E3 ligase activities by disrupting the assembly of COP9 signalosome complex. Biochemical and Biophysical Research Communications, 2013, 432, 425-430.
4. Lou Y-J, Zhang Z-L, Pan X-R, Xu G-P, Jia P-M, Li D, Tong J-H. Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene. Experimental Cell Research, 2011, 317, 513-520.
5. Zhang X-W, Yan X-J, Zhou Z-R, Yang F-F, Wu Z-Y, Sun H-B, Liang W-X, Song A-X, Lallemand-Breitenbach V, Marion J, Zhang Q-Y, Yang H-Y, Huang Q-H, Zhou G-B, Tong J-H, Zhang Y, Wu J-H, Hu H-Y, de The H, Chen S-J, Chen Z. Arsenic trioxide controls the fate of the PML-RARa Oncoprotein by directly binding PML. Science, 2010, 328 (5975), 240-243
6. Lou Y-J, Pan X-R, Jia P-M, Li D, Xiao S, Zhang Z-L, Chen S-J, Chen Z, Tong J-H. IRF-9/STAT2 functional interaction drives RIG-G gene expression independently of STAT1. Cancer Research, 2009, 69 (8):3673-3680.
7. Xiao S, Li D, Zhu H-Q, Song M-G, Pan X-R, Jia P-M, Peng L-L, Dou A-X, Chen G-Q, Chen S-J, Chen Z, Tong J-H. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc.Natl.Acad.Sci.USA, 2006, 103, 16448-16453
8. Wu Y-L, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanvi I, Aradi J, Lanotte M, Tong J-H, Chen G-Q, Segal-Bendirdjian E. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J. Cell. Sci, 2006, 119, 2797-2806
9. Zhao Q, Tao J, Zhu Q, Jia P-M, Dou A-X, Li X, Cheng F, Waxman S, Chen G-Q, Chen S-J, Lanotte M, Chen Z, Tong J-H. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyalocytic leukemia cell differentiation. Leukemia, 2004, 18, 285-292.
10. Zhu Q, Zhang J-W, Zhu H-Q, Shen Y-L, Flexor M, Jia P-M, Yu Y, Cai X, Waxman S, Lanotte M, Chen S-J, Chen Z, Tong J-H. Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood, 2002,99,1014-1022