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孙晓建

研究员,博士生导师

造血干细胞发育和重编程研究共同课题组长
Email: xjsun@sibs.ac.cn

医学基因组学国家重点实验室,副主任

> 研究方向

造血干细胞发育和重编程;白血病发病机制和靶向治疗;表观遗传

> 学习经历

1995.09-1999.07 烟台大学,学士,生物化学专业
2000.09-2005.07 中国科学院上海生命科学研究院,博士,生物化学与分子生物学专业;导师:陈竺
2002.07-2002.10 哈佛大学医学院(Harvard Medical School)丹那-法伯癌症研究所(Dana-Farber Cancer Institute),波士顿儿童医院(Children’s Hospital Boston), 访问学生(Visiting Student);导师:A. Thomas Look,Leonard I. Zon

> 工作简历

2005.07-2007.10 上海市瑞金医院血液学研究所,助理研究员、共同课题组长
2007.10-2013.07 洛克菲勒大学(Rockefeller University),博士后、研究助理(Postdoctoral Associate, Research Associate);导师:Robert G. Roeder
2013.07-2015.08 迈阿密大学医学院(University of Miami Miller School of Medicine),研究助理教授(Research Assistant Professor)
2013.08-至今 洛克菲勒大学(Rockefeller University),兼职教职员(Member of the Adjunct Faculty)
2015.08-至今 上海交通大学医学院附属瑞金医院,上海血液学研究所,研究员、课题组长
医学基因组学国家重点实验室,副主任

> 国家级与省部级科研项目

1. 国家重大科学研究计划课题2013CB966801:基于体细胞重编程和转分化技术获得病人特异的造血干细胞的研究(2013-2017)

2. 国家自然科学基金面上项目81470316:AETFC转录因子复合物的翻译后修饰在急性髓系白血病中的作用机制的研究(2015-2018)

3. 中央组织部青年千人计划:造血和血液肿瘤基因转录调控机制的研究(2015-2018)

4. 上海交通大学医学院高峰高原计划“临床专职科研队伍”:白血病干细胞自我更新的转录和表观遗传调控机制的研究(2015-2017)

> 荣誊

获奖情况

2015 上海交通大学医学院高峰高原计划“临床专职科研队伍”
2015 国家中央组织部青年千人计划
2011 洛克菲勒大学临床与转化医学中心先导项目奖(The Rockefeller University Center for Clinical and Translational Science Pilot Award)
2010 斯塔尔癌症协作组访问学者奖,斯隆-凯特琳癌症中心(Starr Cancer Consortium Visiting Fellow at Memorial Sloan-Kettering Cancer Center)
2006 优秀研究生一等奖,瑞金医院血液学研究所
2005 宝洁优秀博士生奖学金,中国科学院
2005 第一作者讲坛主讲,中国科学院上海生命科学研究院
2005 优秀论文奖,瑞金医院
2003 地奥奖学金二等奖,中国科学院

> 近期主要论文

1. Man,N., Sun,X.J. (共同第一作者), Tan,Y., Cao,M.G., Liu,F., Cheng,G., Hatlen,M., Xu,H., Shah,R., Chastain,N., Liu,N., Huang,G., Zhou,Y., Sheng,M., Song,J., Yang,F.C., Benezra,R., Nimer,S.D., Wang,L. (2016) Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin. Blood, in press
2. Sun,X.J., Man,N., Tan,Y., Nimer,S., Wang,L. (2015) The role of histone acetyltransferases in normal and malignant hematopoiesis. Front. Oncol., 5:108
3. Wang,L., Man,N., Sun,X.J., Tan,Y., Cao,M., Liu,F., Hatlen,M., Xu,H., Huang,G., Mattlin,M., Mehta,A., Rampersaud,E., Benezra,R., Nimer,S. (2015) Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood, 126:640-650
4. Zhang,Y., Xie,S., Zhou,Y., Xie,Y., Liu,P., Sun,M., Xiao,H., Jin,Y., Sun,X., Chen,Z., Huang,Q., Chen,S. (2014) H3K36 Histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm. Cell Rep., 8:1989-2002
5. Sun,X.J., Wang,Z., Wang,L., Jiang,Y., Kost,N., Soong,T.D., Chen,W.Y., Tang,Z., Nakadai,T., Elemento,O., Fischle,W., Melnick,A., Patel,D.J., Nimer,S.D., and Roeder,R.G. (2013). A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature, 500:93-97.
6. Tang,Z., Chen,W.Y., Shimada,M., Nguyen,U.T., Kim,J., Sun,X.J., Sengoku,T., McGinty,R.K., Fernandez,J.P., Muir,T.W., and Roeder,R.G. (2013). SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53. Cell, 154:297-310.
7. Wang,L., Gural,A., Sun,X.J., Zhao,X., Perna,F., Huang,G., Hatlen,M.A., Vu,L., Liu,F., Xu,H., Asai,T., Xu,H., DeBlasio,T., Menendez,S., Voza,F., Jiang,Y., Cole,P.A., Zhang,J., Melnick,A., Roeder,R.G., and Nimer,S.D. (2011). The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science, 333:765-769.
8. Park,J.H., Sun,X.J., and Roeder,R.G. (2010). The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression. Mol. Cell Biol., 30:2750-2761.
9. Hu,M., Sun,X.J. (共同第一作者), Zhang,Y.L., Kuang,Y., Hu,C.Q., Wu,W.L., Shen,S.H., Du,T.T., Li,H., He,F., Xiao,H.S., Wang,Z.G., Liu,T.X., Lu,H., Huang,Q.H., Chen,S.J., and Chen,Z. (2010). Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc. Natl. Acad. Sci. U. S. A, 107:2956-2961.
10. Xu,P.F., Zhu,K.Y., Jin,Y., Chen,Y., Sun,X.J., Deng,M., Chen,S.J., Chen,Z., and Liu,T.X. (2010). Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proc. Natl. Acad. Sci. U. S. A, 107:2521-2526.
11. Sun,X.J., Xu,P.F., Zhou,T., Hu,M., Fu,C.T., Zhang,Y., Jin,Y., Chen,Y., Chen,S.J., Huang,Q.H., Liu,T.X., and Chen,Z. (2008). Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. PLoS. ONE., 3:e1499.
12. Wang,L., Zhao,W.L., Yan,J.S., Liu,P., Sun,H.P., Zhou,G.B., Weng,Z.Y., Wu,W.L., Weng,X.Q., Sun,X.J., Chen,Z., Sun,H.D., and Chen,S.J. (2007). Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death. Differ., 14:306-317.
13. Sun,X.J., Wei,J., Wu,X.Y., Hu,M., Wang,L., Wang,H.H., Zhang,Q.H., Chen,S.J., Huang,Q.H., and Chen,Z. (2005). Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J. Biol. Chem., 280:35261-35271.
14. Song,H.D., Sun,X.J. (共同第一作者), Deng,M., Zhang,G.W., Zhou,Y., Wu,X.Y., Sheng,Y., Chen,Y., Ruan,Z., Jiang,C.L., Fan,H.Y., Zon,L.I., Kanki,J.P., Liu,T.X., Look,A.T., and Chen,Z. (2004). Hematopoietic gene expression profile in zebrafish kidney marrow. Proc. Natl. Acad. Sci. U. S. A, 101:16240-16245.