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陈 冰

副研究员,博士生导师

上海血液学研究所临床诊断实验室和白血病标本库负责人
Email: chenbing.rjsih@yahoo.com

> 研究方向

目前研究重点为:(1) 白血病发病机制研究;(2) 白血病分子分型与个体化治疗研究。

> 学习经历

2005-2009:上海交通大学医学院,血液内科学博士
1998-2001:上海第二医科大学,血液内科学硕士

> 工作简历

2013-至今:上海交通大学医学院附属瑞金医院, 副研究员
2005-2007:法国巴黎圣路易医院医院病理学实验室,出国进修
2004-2012:上海交通大学医学院附属瑞金医院, 助理研究员
2001-2004:上海交通大学医学院附属瑞金医院, 实习研究员

> 国家级与省部级科研项目

主持课题:
1. 国家自然科学基金面上项目,81470311,基于深度测序技术的急性髓细胞白血病(AML)分子分型研究,2015/01-2018/12,75万元,在研,主持
2. 国家自然科学基金面上项目,81270619,M2b 型急性髓细胞白血病的靶向联合治疗机制研究,2013/01-2016/12,75万元,在研,主持
3. 国家高技术研究发展计划(863)课题, 2012AA02A505, 急性粒细胞白血病的分子分型和个体化诊疗技术, 2012/01-2015/12,990万元,已结题,主持
4. 上海市科学技术委员会中药现代化专项, 09dZ1974500, 中药天然产物毛萼乙素治疗多发性硬化的研究, 2009/07-2012/06,50万元,已结题,主持
5. “重大新药创制”国家科技重大专项, 2009ZX09103-431, 血液恶性肿瘤与免疫性疾病治疗药物毛萼乙素的研究, 2009/01-2010/12,143万元,已结题,主持
6. 国家自然科学基金青年科学基金项目,30200110,骨髓增生异常综合症MDS的发病机制研究,2003/01-2005/12,19万元,已结题,主持
参加课题:
7. 国家自然科学基金国际(地区)合作与交流项目,81461148023,发育相关造血转录因子在急性髓细胞中作用的研究-小鼠模型和人类白血病,2014/01-2017/12,200万元,在研,参加
8. 卫生行业科研专项项目, 201202003, 开发白血病分子分型新标志探索个体化治疗新路径, 2013/01-2015/12,2758万元,已结题,参加
9. “重大新药创制”国家科技重大专项, 2013ZX09303302, 血液恶性肿瘤新药临床评价研究技术平台和体系建设, 2013/01-2015/12,468.35万元,已结题,参加
10. 卫生行业科研专项项目, 200902002-1,靶向治疗和细胞治疗的规范化应用研究——白血病药物靶点标准化检测及个体化诊治研究, 2009/08-2012/08, 172万元,已结题,参加
11. 国家自然科学基金创新团体研究项目,30821063,白血病的系统生物学与靶向治疗研究,2009/01-2011/12,500万元,已结题,参加
12. 国家自然科学基金青年科学基金项目,30700335,PRDM1基因beta异构型在弥漫大B细胞性淋巴瘤中的表达及其生物学作用,2008/01-2010/12,17万元,已结题,参加
13. 国家自然科学基金专项基金项目,30623010,白血病系统生物学研究,2007/01-2010/12,120万元,已结题,参加
14. 国家自然科学基金创新团体研究项目,30521003,白血病的系统生物学与靶向治疗研究,2006/01-2008/12,420万元,已结题,参加
15. 国家自然科学基金面上项目,30370300,应用转APL融合基因的细胞株和小鼠模型进行砷剂治疗白血病的机制研究,2004/01-2006/12,20万元,已结题,参加
16. 国家自然科学基金青年科学基金项目,30300139,PRDM1基因beta异构型在弥漫大B细胞性淋巴瘤中的表达及其生物学作用,2004/01-2006/12,18万元,已结题,参加
17. 国家自然科学基金专项基金项目,30123003,恶性肿瘤诱导分化的细胞和分子机制研究,2002/01-2004/12,100万元,已结题,参加
18. 国家自然科学基金面上项目,30070320,t(8;19)易位相关基因的克隆,2001/01-2003/12,13万元,已结题,参加

> 荣誊

2015:上海交通大学医学院高峰高原计划——临床专职科研队伍

> 近期主要论文

1、Yu C, Kong QL, Zhang YX, Weng XQ, Wu J, Sheng Y, Jiang CL, Zhu YM, Cao Q, Xiong SM, Li JM, Xi XD, Chen SJ, Chen B. Clinical significance of day 5 peripheral blast clearance rate in the evaluation of early treatment response and prognosis of patients with acute myeloid leukemia.
J Hematol Oncol. 2015 May 10;8(1):48. doi: 10.1186/s13045-015-0145-1. (通讯作者) IF=4.812

2、Lu Y, Chen B, Song JH, Zhen T, Wang BY, Li X, Liu P, Yang X, Zhang QL, Xi XD, Chen SD, Zuo JP, Chen Z, Chen SJ. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2258-63. doi: 10.1073/pnas.1222426110. Epub 2013 Jan 23. (并列第一作者) IF=9.809

3、B Chen, Y-Y Wang, Y Shen, W-N Zhang, H-Y He, Y-M Zhu, H-M Chen, C-H Gu, X Fan, J-m Chen, Q Cao, G Yang, C-L Jiang, X-Q Weng, X-X Zhang, S-M Xiong, Z-X Shen, H Jiang, L-J Gu, Z Chen, J-Q Mi and S-J Chen. Newly diagnosed acute lymphoblastic leukemia in China (I):abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries. Leukemia. 2012 Jul;26(7):1608-16. doi: 10.1038/leu.2012.26. Epub 2012 Feb 7.(第一作者)IF=10.164

4、Mi JQ, Wang X, Yao Y, Lu HJ, Jiang XX, Zhou JF, Wang JH, Jiao B, Shen SH, Tang JY, Gu LJ, Jiang H, Ma LY, Hao SG, Chen FY, Xiong SM, Shen ZX, Chen Z, Chen B, Chen SJ. Newly diagnosed acute lymphoblastic leukemia in China (II): Prognosis related to genetic abnormalities in a series of 1 091 cases. Leukemia. 2012 Jul;26(7):1507-16. doi: 10.1038/leu.2012.23. Epub 2012 Feb 2.(并列通讯作者)IF=10.164

5、Chen B, Zhao WL, Jin J, Xue YQ, Cheng X, Chen XT, Cui J, Chen ZM, Cao Q, Yang G, Yao Y, Xia HL, Tong JH, Li JM, Chen J, Xiong SM, Shen ZX, Waxman S, Chen Z, Chen SJ. Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries. Leukemia. 2005 May;19(5):767-75. (第一作者)IF=6.612

6、Liu H, Chen B, Xiong H, Huang QH, Zhang QH, Wang ZG, Li BL, Chen Z, Chen SJ. Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene. 2004 Apr 22;23(19):3385-94. (并列第一作者) IF=6.318

7、Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ. Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7640-5. (并列第一作者) IF=10.452

8、Zhao H, Liu P, Zhang R, Wu M, Li D, Zhao X, Zhang C, Jiao B, Chen B, Chen Z, Ren R. Roles of palmitoylation and the KIKK membrane-targeting motif in leukemogenesis by oncogenic KRAS4A. J Hematol Oncol. 2015,8:132. IF=4.812

9、Shen Y, Fu YK, Zhu YM, Lou YJ, Gu ZH, Shi JY, Chen B, Chen C, Zhu HH, Hu J, Zhao WL, Mi JQ, Chen L, Zhu HM, Shen ZX, Jin J, Wang ZY, Li JM, Chen Z, Chen SJ. Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide. EBioMedicine. 2015 Apr 12;2(6):563-71. doi: 10.1016/j.ebiom.2015.04.006. eCollection 2015 Jun.

10、Xu L, Gu ZH, Li Y, Zhang JL, Chang CK, Pan CM, Shi JY, Shen Y, Chen B, Wang YY, Jiang L, Lu J, Xu X, Tan JL, Chen Y, Wang SY, Li X, Chen Z, Chen SJ. Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers.
Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8589-94. doi: 10.1073/pnas.1407688111. Epub 2014 May 21. IF=9.674

11、Weng XQ, Shen Y, Sheng Y, Chen B, Wang JH, Li JM, Mi JQ, Chen QS, Zhu YM, Jiang CL, Yan H, Zhang XX, Huang T, Zhu Z, Chen Z, Chen SJ. Prognostic significance of monitoring leukemia-associated immunophenotypes by eight-color flow cytometry in adult B-acute lymphoblastic leukemia. Blood Cancer J. 2013 Aug 16;3:e133. doi: 10.1038/bcj.2013.31. IF=1.4

12、Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang T. RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13522-7. doi: 10.1073/pnas.1310067110. Epub 2013 Jul 29. IF=9.737

13、Shen Y, Zhu YM, Fan X, Shi JY, Wang QR, Yan XJ, Gu ZH, Wang YY, Chen B, Jiang CL, Yan H, Chen FF, Chen HM, Chen Z, Jin J, Chen SJ. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood. 2011 Nov 17;118(20):5593-603. Epub 2011 Aug 31. IF=9.898

14、Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. Int J Cancer. 2011 Jan 1;128(1):233-8. doi: 10.1002/ijc.25318. IF=5.444

15、Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX. An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation. Blood. 2010 Jun 10;115(23):4715-24. Epub 2010 Apr 6. IF=9.898

16、Jiao B, Wu CF, Liang Y, Chen HM, Xiong SM, Chen B, Shi JY, Wang YY, Wang JH, Chen Y, Li JM, Gu LJ, Tang JY, Shen ZX, Gu BW, Zhao WL, Chen Z, Chen SJ. AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2. Leukemia. 2009 Sep;23(9):1598-604. Epub 2009 May 21. IF=9.561

17、Hu J, Liu YF, Wu CF, Xu F, Shen ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3342-7. Epub 2009 Feb 18. IF=9.681

18、Pan Q, Zhu YJ, Gu BW, Cai X, Bai XT, Yun HY, Zhu J, Chen B, Weng L, Chen Z, Xue YQ, Chen SJ. A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation. Oncogene. 2008 May 29;27(24):3414-23. Epub 2007 Dec 17. IF=6.373

19、Ma LH, Liu H, Xiong H, Chen B, Zhang XW, Wang YY, Le HY, Huang QH, Zhang QH, Li BL, Chen Z, Chen SJ. Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis. Blood. 2007 Jan 15;109(2):769-77. Epub 2006 Sep 21. IF=9.898

20、Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.
Clin Cancer Res. 2006 May 15;12(10):3043-9. Erratum in: Clin Cancer Res. 2009 Feb 15;15(4):1506. IF=7.742

21、Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1104-9. Epub 2005 Jan 13. IF=9.681

22、Gu BW, Wang Q, Wang JM, Xue YQ, Fang J, Wong KF, Chen B, Shi ZZ, Shi JY, Bai XT, Wu DH, Chen Z, Chen SJ. Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity. Leukemia. 2003 Sep;17(9):1858-64. IF=6.612

23、Xia HL, Chen LJ, Chen B, Jin XL, Chen SJ. The molecular cytogenetic aberration analyzed by comparative genomic hybridization and its significance in diffuse large B-cell lymphoma. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Feb;23(1):12-5.

24、Chen LJ, Dong Y, Chen SY, Zhang L, Zhou GB, Chen B, Wang L, Chen Z, Chen SJ. [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Dec;13(6):924-31. Chinese.

25、Zhao M, Chen B, Wang L, Xu L, Cao Q, Su X, Chen SJ. [Establishment and application of multiplex FISH in detection of the complex chromosome abnormalities in leukemia] Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Oct;19(5):375-8. Chinese.

26、夏海龙,闵大六,王志国,陈丽娟,陈冰,金小龙,陈竺,陈赛娟. BCL-2、Ki-67、CyclinD1在弥漫性大B细胞淋巴瘤中表达的临床意义. 《中国组织化学与细胞化学杂志》2005年03期

27、夏海龙,陈丽娟,陈冰,刘元华,杨光,曹琪,姚颖,陈赛娟. 应用比较基因组杂交技术研究淋巴瘤细胞遗传学异常与临床的关系. 中华内科杂志[CHINESE JOURNAL OF INTERNAL MEDICINE] 2005 Vol.44 No.10 P.774-776

28、《临床血液细胞学图谱与应用》 副主编
主编:熊树民、余润泉,上海交通大学出版社, 2009年

29、《人类基因组研究基本技术》 参与编撰
主编:陈赛娟,人民军医出版社,2001年

30、《血液恶性疾病基因异常和靶向治疗》 参与编撰
主编:陈赛娟,上海科学技术出版社,2006年

31、《恶性淋巴瘤》第二版 参与编撰
主编:沈志祥、朱雄增,人民卫生出版社,2011年

32、《血液肿瘤骨髓诊断图谱》 参与编撰