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王月英

研究员,博士生导师

基因和免疫治疗研究课题组组长
Email: yywang@shsmu.edu.cn

> 研究方向

(1)白血病发病机制和靶向治疗;(2) CAR-T细胞免疫治疗

> 学习经历

2000.09-2005.06:上海交通大学医学院,遗传学专业,导师:陈竺教授,博士
1995.09-2000.06:上海第二医科大学(现上海交通大学医学院),医学学士

> 工作简历

2013.01至今:上海交通大学医学院附属瑞金医院,研究员。
2008.08-2012.12:上海交通大学医学院附属瑞金医院,副研究员。
2009.09-2010.09:美国布兰迪斯大学(Brandeis University)生物系Rosenstiel基础医学科学研究中心,访问学者。
2005.07-2008.07:上海交通大学医学院附属瑞金医院,助理研究员。

> 国家级与省部级科研项目

作为第一负责人,承担国家级课题4项,省部级课题3项。
1. 国家自然科学基金-优秀青年科学基金(编号:81222004)
2. 国家科技重大专项-新药创制(编号:2013ZX09102001)
3. 国家自然科学基金-面上项目(编号:81570151)
4. 国家自然科学基金-青年科学基金项目(编号:30600362)
5. 上海青年科技启明星计划(跟踪)(编号:12QH1401500)
6. 上海青年科技启明星计划(编号:08QA1404800)
7. 上海市人才发展基金资助(编号:201458)

> 荣誊

2015年国家自然科学奖二等奖(第三完成人)
2014年上海市自然科学奖特等奖(第三完成人)
2012年获国家自然科学基金优秀青年科学基金
2013年上海市卫生系统第十四届银蛇奖三等奖
2012年上海市青年科技启明星(跟踪)
2014年民治生命科学奖优秀奖

> 近期主要论文

1. Xu J, Wang YY*, Dai YJ, Zhang W, Zhang WN, Xiong SM, Gu ZH, Wang KK, Zeng R, Chen Z, Chen SJ. DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells. Proc Natl Acad Sci USA. 2014. 111(7):2620-2625. (*并列通讯作者,并列第一作者)
2. Wang YY, Zhao LJ, Wu CF, Liu P, Shi L, Liang Y, Xiong SM, Mi JQ, Chen Z, Ren R, Chen SJ. C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci U S A. 2011. 108 (6): 2450-2455.
3. Wang YY , Zhou GB , Yin Tong et al. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A. 2005; 102(4):1104-1109.
4. Zhao LJ, Wang YY, Li G, Ma LY, Xiong SM, Weng XQ, Zhang WN, Wu B, Chen Z, Chen SJ. Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia. Blood. 2012. 119(12):2873-2882. (并列第一作者)
5. Chen B, Wang YY, Shen Y, Zhang WN, He HY, Zhu YM, Chen HM, Gu CH, Fan X, Chen JM, Cao Q, Yang G, Jiang CL, Weng XQ, Zhang XX, Xiong SM, Shen ZX, Jiang H, Gu LJ, Chen Z, Mi JQ, Chen SJ. Newly diagnosed acute lymphoblastic leukemia in China (I): Abnormal genetic patterns in 1346 childhood and adult cases and their comparison to the reports from Western countries. Leukemia. 2012. 26: 1608-1616. (并列第一作者)
6. Wang L, Wang YY, Cao Q, Chen Z, Chen SJ. Hornerin gene was involved in a case of acute myeloid leukemia transformed from myelodysplastic syndrome with t(1;2)(q21;q37). Leukemia. 2006; 20:2184-2187. (并列第一作者)
7. Pan MM, Zhang QY, Wang YY, Liu P, Ren RB, Huang JY, Chen LT, Xi XD, Chen Z, Chen SJ. Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway. Leukemia 2015 doi: 10.1038.
8. Xu L, Gu ZH, Li Y, Zhang JL, Chang CK, Pan CM, Shi JY, Shen Y, Chen B, Wang YY, Jiang L, Lu J, Xu X, Tan JL, Chen Y, Wang SY, Li X, Chen Z, Chen SJ. Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers. Proc Natl Acad Sci USA 2014; 111:8589-8594
9. Chen WL, Wang JH, Zhao AH, Xu X, Wang YH, Chen TL, Li JM, Mi JQ, Zhu YM, Liu YF, Wang YY, Jin J, Huang H, Wu DP, Li Y, Yan XJ, Yan JS, Li JY, Wang S, Huang XJ, Wang BS, Chen Z, Chen SJ, Jia W. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood 2014; 124:1645-1654.
10. Wang YY. Genetic and epigenetic changes contributing to leukemogenesis and prognostic impact in acute myeloid leukemia. 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH),S6-S6,Vienna, Austria,2013.8.22-2013.8.25。
11. Zhen T, Wu CF, Liu P, Wu HY, Zhou GB, Lu Y, Liu JX, Liang Y, Li KQ, Wang YY, Xie YY, He MM, Cao HM, Zhang WN, Chen LM, Petrie K, Chen SJ, Chen Z. Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. Science Translational Medicine 2012; 4:127-138.
12. Xu J,Zhang WN,Zhen T,Li Y,Shi JY,Mi JQ,Wang YY,Chen SJ,Chen Z,DNMT3A Mutation Leads to Hematopoietic Dysregulation,54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH),Atlanta, GA,2012.12.8-2012.12.11.
13. Jiao B, Wu CF, Liang Y, Chen HM, Xiong SM, Chen B, Shi JY, Wang YY, Wang JH, Chen Y, Li JM, Gu LJ, Tang JY, Shen ZX, Gu BW, Zhao WL, Chen Z, Chen SJ. AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2. Leukemia 2009; 23:1598–1604.
14. Zhang SJ, Ma LY, Huang QH, Li G, Gu BW, Gao XD, Shi JX, Wang YY, Gao L, Cai X, Ren RB, Zhu J, Chen Z, Chen SJ. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acid Sci USA 2008;105:2076-2081
15. Ma LH, Liu H, Xiong H, Chen B, Zhang XW, Wang YY, Le HY, Huang QH, Zhang QH, Li BL, Chen Z, Chen SJ. Aberrant Transcriptional Regulation of the MLL Fusion Partner EEN Gene by AML1-ETO and Its Implication in Leukemogenesis. Blood 2007; 109:769-777.