首页 > 科学研究 > 止血与血栓及基因治疗课题组

> 课题组简介

  本课题组研究工作的总体目标为结合分子生物学和细胞生物学等研究方法,探讨止血与血栓形成过程中的关键机制。在阐明止血与血栓形成相关的关键生物分子结构/功能关系和重要信号转导通路及其调控方式的基础上,促进对血栓性或出血性病发病机理的认识并推动相应疾病的诊断和防治,同时关注遗传性出血性疾病的基因治疗研究。此外,从对砷剂的靶蛋白及其相互作用规律的探索研究入手,拓展其在肿瘤治疗方面的应用。

> 课题组长:奚晓东


> 代表性论文

1. Shi X, Yang J, Cui X, Huang J, Long Z, Zhou Y, Liu P, Tao L, Ruan Z, Xiao B, Zhang W, Li D, Dai K, Mao J, Xi X: Functional effect of the mutations similar to the cleavage during platelet activation at integrin β3 cytoplasmic tail when expressed in mouse platelets. PLoS One 2016; 11(11):e0166136

2. Huang J, Zhou Y, Su X, Lyu Y, Tao L, Shi X, Liu P, Long Z, Ruan Z, Xiao B, Xi W, Zhou Q, Mao J, Xi X: Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model. Front Med 2016; 10(3):311-19

3. Shi X, Yang J, Huang J, Long Z, Ruan Z, Xiao B, Xi X: Effects of different shear rates on the attachment and detachment of platelet thrombi. Mol Med Rep 2016; 13(3):2447-56

4. Huang J, Shi X, Xi W, Liu P, Long Z, Xi X: Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy. J Hematol Oncol 2015; 8:62

5. Yan J, Wang K, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen JP, Chen S, Chen Z, Xi X: PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association. Proc Natl Acad Sci U S A 2010; 107:3716

6. Mao JH, Sun XJ, Liu JX, Zhang QY, Liu P, Huang QH, Li KQ, Chen Q, Chen Z, Chen SJ: As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia. Proc Natl Acad Sci USA 2010; 107:21683

7. Su X, Mi J, Yan J, Flevaris P, Lu Y, Liu H, Ruan Z, Wang X, Kieffer N, Chen S, Du X, Xi X: RGT, a synthetic peptide corresponding to the integrin β3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin αIIbβ3 with Src kinase. Blood 2008; 112:592