首页 > 科学研究 > 肿瘤细胞分化和凋亡途径研究课题组

> 课题组简介

  本课题组的研究方向主要是白血病(肿瘤)细胞分化、增殖、凋亡等相关机制的研究。通过对基因功能、表达调控以及细胞应激反应的研究,鉴定新的分化(或凋亡)诱导剂、人类疾病(特别是肿瘤)靶标或生物学标志,最终达到临床转化应用的目的。

> 课题组长:童建华、刘晗


> 代表性论文

1. Tan YT, Sun Y, Zhu SH, Ye L, Zhao CJ, Zhao WL, Chen Z, Chen SJ#, Liu H#. Deregulation of HOX genes by DNMT3A and MLL mutations converges on BMI1. Leukemia (2016) doi: 10.1038/leu.2016.15.

2. Lou YJ, Pan XR, Jia PM, Jin J, Tong JH. RIG-G inhibits the proliferation of NB4 cells and propels ATRA-induced differentiation of APL cells. Leukemia Research (2016) 40:83-89.

3. Zhuang LK, Xu GP, Pan XR, Lou YJ, Zou QP, Xia D, Yan WW, Zhang YT, Jia PM, Tong JH. MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation. Cell Death & Disease (2014) 5:e1161.

4. Liu H, Westergard TD, Cashen A, Piwnica-Worms DR, Kunkle L, Vij R, Pham CG, DiPersio J, Cheng EH, Hsieh JJ. Proteasome Inhibitors Evoke Latent Tumor Suppression Programs in Pro-B MLL Leukemias Through MLL-AF4. Cancer Cell (2014) 25(4):530-42.

5. Xu GP, Zhang ZL, Xiao S, Zhuang LK, Xia D, Zou QP, Jia PM, Tong JH. Rig-G negatively regulates SCF-E3 ligase activities by disrupting the assembly of COP9 signalosome complex. Biochemical and Biophysical Research Communications (2013) 432:425-430.

6. Lou YJ, Zhang ZL, Pan XR, Xu GP, Jia PM, Li D, Tong JH. Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene. Experimental Cell Research (2011) 317: 513-520.