首页 > 科学研究 > 血液病和感染性疾病的结构生物学研究课题组

> 课题组简介

  本课题组主要从事血液病和感染性疾病的结构生物学和临床转化医学研究。上海交通大学医学院附属瑞金医院上海血液学研究所/医学基因组学国家重点实验室在精准医学(特别是血液肿瘤的基础和临床转化)的研究,为结构生物学和临床转化型靶点治疗研究奠定了雄厚的基础。蒙国宇团队主要通过以生物信息学,结构生物学,分子生物学、细胞生物学和动物模型等技术平台,对PML-RARA (acute promyelocytic leukemia, APL), DUX4-IGH (acute lymphoblastic leukemia, ALL), Saf (biofilm and bacterial infection diseases)等血液肿瘤和感染性疾病中的重要靶点蛋白的结构和功能进行系统的分析,设计和改善现有的小分子药物,寻找新的治疗药物和治疗诊断方法。

> 课题组长:蒙国宇


> 代表性论文

1. L. Zeng¥, L. Zhang¥, G. Meng@ (2017) Structural basis of host recognition and biofilm formation by Salmonella Saf pili (Submitted)
2. P. Wang¥, S. Benhenda, H. Wu¥, V. Lallemand-Breitenbach, T. Zhen, F. Jollivet, L. Peres, Y. Li¥, S.J. Chen, Z. Chen, H. de The, G. Meng@ (2017) RING tetramerization is required for nuclear body biogenesis and PML auto-sumoylation. (Submitted)
3. X. Dong¥, W. Zhang, H. Wu¥, J. Huang, M. Zhang, P. Wang¥, H. Zhang¥, Z. Chen, S.J. Chen, G. Meng@ (2017) DUX4-DRE recognition is required for transactivation and B-ALL leukemogenesis. (Submitted)
4. X. Li, S. Thome, X. Ma¥, M. Amrute-Nayak, A. Finigan, L. Kitt, L. Masters, J. James, Y. Shi, G. Meng, Z. Mallat (2017) MARK4 controls subcellular NLRP3 positioning to regulate inflammasome activation. Nat Commun. doi: 10.1038/ncomms15986
5. J. Lei¥, X. Cai¥, X. Ma¥, L. Zhang¥, Y. Li¥, X. Dong¥, J. St Geme III, G. Meng@ (2015) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of Haemophilus influenzae BamD and BamCD complex. Acta Cryst. F71, doi:10.1107/S2053230X14027319
6. L. Jiang, Z. Gu, Z. Yan, X. Zhao, Y. Xie, Z. Zhang, C. Pan, Y. Hu, C. Cai, Y. Dong, J. Huang, L. Wang, Y. Shen, G. Meng, J. Zhou, J. Hu, J. Wang, Y. Liu, L. Yang, F. Zhang, J. Wang, Z. Wang, Z. Peng, F. Chen, Z. Sun, H. Ding, J. Shi, J. Hou, J. Yan, J. Shi, L. Xu, Y. Li, J. Lu, Z. Zheng, W. Xue, W. Zhao, Z. Chen, S.J. Chen@ (2015) Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma; Nat Genetics. doi:10.1038/ng.3358
7. L.T. Chen, W.X. Liang¥, S. Chen, R.K. Li, J.L. Tan, P.F. Xu, L.F. Luo, L. Wang, S.H. Yu, G. Meng, K.K. Li, T.X. Liu, Z. Chen, S.J. Chen@ (2014) Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Nat Commun. doi: 10.1038/ncomms4811.
8. R. Xiao¥, X.D. Xi, Z. Chen, S.J. Chen, G. Meng@ (2013) Structural framework of c-Src activation by integrin 3. Blood, 24;121(4):700-6
9. G. Meng@, N. Spahich, R. Kenjale, G. Waksman, J. St Geme (2011) Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation. EMBO J. 30: 3864-3874.
10. X. Cai¥, R. Wang, A. Filloux, G. Waksman, G. Meng@ (2011) Structural and Functional Characterization of Pseudomonas aeruginosa CupB Chaperones. PLoS ONE 6(1): e16583.